<p>The Effect of A1 Adenosine Receptor in Diabetic Megalin Loss with Caspase-1/IL18 Signaling [Corrigendum]</p>

Selective Inhibitory Effect of Adenosine A1 Receptor Agonists on the Proliferation of Human Tumor Cell Lines

Background: In this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. Previous research showed a cytotoxic effect of adenosine via A3 receptor and A1 receptor and sometimes this effect was receptor independent. The researches showed a differential cytotoxic effect of adenosine and its A3 agonists on cancerous cells, while ot...

Natriuretic effect of adenosine A1-receptor blockade in rats.

BACKGROUND Many effects of adenosine on renal function have been identified. The development of adenosine receptor blockers has made it possible to identify which of these effects are exerted by endogenous adenosine. At least four adenosine receptor subtypes, denoted A1, A2a, A2b, and A3 are currently known. In the present study the selective A1 receptor blocker 1,3-dipropyl-8[2-(5,6-epoxy) nor...

Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor.

For decades, it has been thought that adenosine is exclusively antimitogenic on vascular smooth muscles via the A2-type adenosine receptor. Recently, we have demonstrated that adenosine stimulates proliferation of porcine coronary artery smooth muscle cells (CASMC) through the A1 adenosine receptor. However, the cell-signaling mechanisms underlying A1 receptor-mediated CASMC proliferation in re...

PET imaging of adenosine A1 receptor occupancy.

Anxiolytic properties of A1 adenosine receptor PAMs

Anxiety and anxiety disorders are among the most prevalent mental health conditions worldwide. Despite the high prevalence rates, anxiety is often an underestimated and undertreated clinical problem. Current treatment strategy for the management of anxiety mainly involves the use of selective serotonin reuptake inhibitors and benzodiazepines. Although widely prescribed and effective in reducing...